I have D5 Render running on my old computer with dual Xeon E 5345 and AMD Raedon HD 78950 series, first I reject the graphics board, but I could open it with the trick of modifying the config, despite opening the program it is unusable due to the slowness of the graphic plate. The recommendation of 1060 rtx is I think because the program needs it.
I also have the program running on two other machines, one with Nvidia gtx1080, and the other with Nvidia gtx 2080 ti, not only is there a big difference but I never had any problems, using the soft with three big projects to test it.
But I can tell you that both machines render in 2K, 4K, 6K and movies render test are four times faster in 2080 ti than in 1080, when in one the timeline was at 25% in the other the task is already done. that in all the tests I did.